Hastings Hotel Group has won approval for the £30m Belfast Grand Central Hotel by 2018, with the creation of 150 jobs.
The four-star, 200-bedroom hotel, which will feature a restaurant and bar, 16 serviced apartments, ground floor retail units, and a range of office accommodation, will be the firm's seventh site.
The new addition will bring the number of bedrooms in the group to over 1,000.